A nurse is preparing to administer amphotericin B lipid complex via intermittent IV bolus to a client who has infective endocarditis. Which of the following actions should the nurse take?

Amphotericin B lipid complex (ABLC) is an antifungal medication used for serious systemic fungal infections such as infective endocarditis. According to standard administration guidelines, ABLC should be infused at a rate of 2.5 mg/kg/hr, which typically results in infusion times of approximately 2 hours for standard doses, making administering the medication over 2 hours the correct action. Using a gravity flow set is incorrect; ABLC should be administered with an infusion pump to control the rate precisely and reduce the risk of infusion-related reactions. Priming the tubing with 0.9% sodium chloride is incorrect because ABLC is incompatible with saline solutions — it should only be mixed with and administered through lines containing 5% dextrose in water (D5W). Discarding the medication if it is yellow is incorrect; amphotericin B lipid complex has a yellow to amber color as a normal characteristic of the product and should not be discarded on this basis. Students should remember the incompatibility with normal saline, the required use of an infusion pump, and the expected yellow color as key administration considerations for this high-alert antifungal medication.