RN Nursing · Pancreatitis · Practice question
A nurse is teaching a client who has pancreatitis about enzyme replacement therapy. Which of the following client statements indicate an understanding of the teaching?
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"l will chew the tablets thoroughly before swallowing."
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"l will be more likely to sunburn while taking this medication."
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✓
"l will drink 8 ounces of water with the medication."
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"l will take the medication with an antacid for stomach upset."
Answer & explanation
Correct: "l will drink 8 ounces of water with the medication."
Pancreatic enzyme replacement therapy (PERT), typically in the form of pancrelipase capsules or tablets, should be taken with adequate fluid to facilitate swallowing and prevent irritation to the oral mucosa and esophagus. Drinking 8 ounces of water with the medication is correct technique and demonstrates understanding of safe administration. Chewing the tablets thoroughly before swallowing is incorrect and potentially harmful; enzyme preparations should be swallowed whole or, if capsules, the beads can be sprinkled on soft food but never chewed, as chewing destroys the enteric coating and can cause severe mucosal irritation in the mouth and esophagus. Taking the medication with an antacid is also contraindicated because antacids (especially calcium- or magnesium-based) can inactivate pancreatic enzymes, reducing their therapeutic effectiveness; in fact, if adjunct therapy is needed for gastric acid suppression, a proton pump inhibitor or H2 blocker is preferred. The statement about increased risk of sunburn reflects a side effect associated with some other medications, such as tetracyclines or fluoroquinolones, and is not relevant to pancreatic enzyme replacement. The statement about drinking water is therefore the correct indicator of client understanding.
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