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LPN Nursing · Substance Use Disorders · Practice question

The fact that an alcoholic with a blood alcohol level well above the legal limit of intoxication can walk without stumbling, talk without slurring speech, and continue to perform at some level on the job is a result of which phenomenon?

Answer & explanation

Correct: Tolerance

Tolerance is the physiological phenomenon in which the body adapts to a substance over time, requiring increasingly larger amounts to achieve the same effect, or — as illustrated here — in which a person functions at levels that would incapacitate a non-user despite having a blood alcohol concentration well above legal intoxication thresholds. Chronic alcohol abusers develop neurological tolerance such that their brains have adapted to the depressant effects of alcohol, allowing them to maintain motor function, speech, and occupational performance at blood alcohol levels that would cause significant impairment or unconsciousness in someone without this adaptation. Codependency refers to an unhealthy relationship dynamic in which one person enables another's substance use — it does not describe physiological adaptation. Cross-tolerance occurs when tolerance to one substance results in tolerance to a pharmacologically similar substance; this is a different concept and is not what is being described. Substance dependence is a broader clinical diagnosis involving compulsive use despite negative consequences; it does not specifically explain why function is maintained at high blood alcohol levels. Only tolerance directly explains the ability to function normally at blood alcohol concentrations that would otherwise cause profound intoxication in a non-tolerant individual.

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