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RN Nursing · Pathophysiology · Practice question

Which statement about blood pH is correct?

Answer & explanation

Correct: Ranges 7.35–7.45

The normal physiological pH of arterial blood is maintained within a narrow range of 7.35 to 7.45. This tight regulation is critical because even small deviations can significantly impair enzyme function, cellular metabolism, and organ function. The pH is maintained by buffer systems including the bicarbonate-carbonic acid system, the phosphate buffer system, and proteins such as hemoglobin, working in concert with respiratory and renal compensation. The statement that blood pH is always exactly 7.4 is imprecise; while 7.4 is often cited as the mean or ideal value, the accepted normal range spans from 7.35 to 7.45, and values within this range are considered normal. The statement that blood is more acidic than water is incorrect; pure water has a neutral pH of 7.0, and blood with a pH of 7.35–7.45 is actually slightly alkaline relative to neutral. The statement that pH must be below 7.0 is clinically dangerous — a pH below 7.35 constitutes acidosis, and a pH below 7.0 is incompatible with life. Students should remember that pH values below 7.35 indicate acidosis and values above 7.45 indicate alkalosis, both of which require clinical intervention.

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